![]() "One of the major problems in transplantation is maintaining blood flow in the organ," said Shay Soker, a professor of regenerative medicine at the Wake Forest Institute for Regenerative Medicine. However, such scaffolds typically lack the structural equivalent of a vascular network. The majority of scaffolds used in engineered tissue constructs are fabricated de novo from combinations of natural and synthetic biomaterials. 1,2 The findings provide further evidence that unusable donor organs could serve as the scaffold for engineering replacement organs. Research groups at Harvard Medical School and Yale University separately have developed protocols for using decellularized matrices to generate transplantable liver and lung grafts that have functional vascular systems.
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